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Evaluation of effects of photooxidized Vespa orientalis venom on memory and learning in rats J. Venom. Anim. Toxins incl. Trop. Dis.
Mukund,H; Gawade,SP.
Wasp venom is mixture of complex proteins that have several physical and pharmacological properties. The photochemical detoxification of Vespa orientalis venom is expected to generate photooxidized venom sac extract (PVSE). Antigenically active PVSE is obtained by exposing the venom sac extract (VSE) of Vespa orientalis to ultraviolet radiation in the presence of methylene blue. The aim of the present work was to evaluate the effect of PVSE on learning and memory of rats. Detoxification of PVSE was evident since treated mice had longer survival time than the group of mice treated with VSE. Photooxidized VSE of V. orientalis revealed enhancement on learning and memory by shortening the time to reach food (TRF) in T-maze. In a 28-day study with rats, we...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Vespa venom; Photochemical processes; Learning; Memory; Maze learning.
Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992011000400009
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